nombre viagra generico mexico N compartments. It is likely that the mechanisms leading to monocyte activation not only promote cns disease, but also promote further increases in virus replication and potentially contribute to drug resistant reservoirs in hiv infected patients. Results of our studies in human tissues derived from autopsy specimens demonstrate that the perivascular macrophage is the major reservoir for productive hiv infection in the cns in hiv encephalitis. In addition, cells with ramified microglial morphology in brain parenchyma are also productively infected. There is a large increase in both populations of macrophages/microglia in hive. Having ruled out proliferation as a mechanism for the increased number of these cells, our studies now focus on trafficking of monocyte/macrophages in hive. cheap viagra online cheap viagra viagra for sale cheap viagra in canada viagra for sale viagra without a doctor prescription generic viagra online cheap generic viagra generic viagra online Indeed, other organs including kidney, liver, lymph node and spleen exhibit invasion of monocyte/macrophages in patients with hive. Viral genetic analysis of individual cell subsets is currently in progress to determine if hiv evolution is compartmentalized within the cns or alternatively, if similar viral sequences are found in various organs and tissues. In order to investigate if altered monocyte/macrophage trafficking is involved in the pathogenesis of hive, studies are in progress to investigate the time-course of accumulation, organ invasion and trafficking kinetics in an animal model for hiv induced cns disease. We are currently investigating alterations in monocyte/ macrophage homeostasis in siv infected macaques resulting in the expansion of an altered monocyte subset expressing the fc receptor cd16. We are investigating the rate of production, clearance, as well as the consequent changes in immune polarization. In addition, we are using multiplex and bioinformatics approaches to study a number of candidate genes and biomarkers involved in this process. We are further exploring candidate compounds that may have the capacity to normalize monocyte/macrophage production, differentiation, and activation, with the goal of interfering with the harmful effects of macrophages on the immune system and cns. This project is in collaboration with tracy fischer-smith and mark g. Lewis (bioqual, inc).   effect of drugs of abuse in aids pathogenesis: in collaboration with thomas rogers, tracy fischer-smith, kamel khalili, toby eisenstein, and mark lewis, we are investigating the effect of morphine on the pathogenesis of aids in non-human primates. This study should provide information regarding the impact of drugs of abuse on the development of aids and cns disease in humans who are addicted to heroin. These studies involve virologic as well as biologic evaluations including immune and tissue based studies. Return to top     return to top     educational background research interests pubmed publications r.